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Article

Modulation of amyloid-β protein precursor expression by HspB1.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Conway Megan, Nafar Firoozeh, Straka Tatjana, Mearow Karen

Abstract excerpt

Upregulation of heat shock proteins, such as Hsp70 and HspB1/Hsp27, have been associated with an amelioration of the deficits in animal models of Alzheimer's disease (AD). HspB1 is reported to be increased in AD brains and to accumulate in plaques, but whether this localization is an attempt by HspB1 to ameliorate the detrimental effects of amyloid-β (Aβ) on cells or part of the disease process is unknown. Here...

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Identifiers

PMID: 24898650
DOI: 10.3233/JAD-140348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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