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Article

Inactivation of Apaf1 reduces the formation of mutant huntingtin-dependent aggregates and cell death.

Neuroscience - 14 Mar 2014

Sancho M, Herrera A E, Orzáez M, Pérez-Payá E

Abstract excerpt

Polyglutamine expansions in some proteins associated with neurodegenerative diseases, such as Huntington's disease or several ataxias, lead to insoluble aggregates in the cell. These aggregates accumulate through a mechanism that is not yet fully understood, but it activates cell death pathways and contributes to kill the cell. Here, we show that apoptotic protease activating factor 1 (Apaf1) down-regulation, or...

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Identifiers

PMID: 24412373
DOI: 10.1016/j.neuroscience.2013.12.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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