Article
Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice.
Proceedings of the National Academy of Sciences of the United States of America - 17 Oct 2023
Montenegro Paola, Chen Phoenix, Kang Jongkyun, Lee Sang Hun, Leone Sofia, Shen Jie
Abstract excerpt
Mutations in the Presenilin (PSEN1 and PSEN2) genes are the major cause of early-onset familial Alzheimer's disease (FAD). Presenilin (PS) is the catalytic subunit of the γ-secretase complex, which cleaves type I transmembrane proteins, such as Notch and the amyloid precursor protein (APP), and plays an evolutionarily conserved role in the protection of neuronal survival during aging. FAD PSEN1 mutations exhibit...
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