Article

<i>In Silico</i> Design of APOE ɛ4 Interaction Inhibitor Peptides for Alzheimer’s Disease

2025-09-07

Abstract excerpt

<h4>Background</h4> Protein-protein interactions (PPIs) are essential for cellular functions, and their aberrant formation contributes to neurodegenerative diseases. Alzheimer’s disease (AD), characterized by its complex pathogenesis, poses an increasing societal burden with population aging. The APOE ɛ4 allele represents the strongest genetic risk factor for late-onset AD, yet its pathological mechanisms remain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce4785ac-15af-5f88-a73f-621405007b3f
DOI: 10.1101/2025.09.03.673973

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In Silico</i> Design of APOE ɛ4 Interaction Inhibitor Peptides for Alzheimer’s DiseaseDOI 10.1101/2025.09.03.673973Read

Drug Target Prioritization for Alzheimer's Disease Using Protein Interaction Network AnalysisSemantic proximity Read

AI-guided design and <i>ex vivo</i> validation of nanobodies targeting aggregation motifs of intrinsically disordered protein tauSemantic proximity Read

AI-Guided Dual Strategy for Peptide Inhibitor Design Targeting Structural Polymorphs of α-Synuclein FibrilsSemantic proximity Read

Peptide Design through Binding Interface MimicrySemantic proximity Read

Integrative bioinformatics analysis of APOE variants in Alzheimer's disease and clinical therapeutics.Semantic proximity Read

Computational prediction of high-risk non-synonymous SNPs in human ApoE and their structural impact on amyloid-β interaction in Alzheimer’s disease pathogenesisSemantic proximity Read

Optimizing Open Source Tools for Protein Design, Characterization, and Docking in Alzheimer's Disease Drug DevelopmentSemantic proximity Read

Artificial intelligence for drug discovery and development in Alzheimer's diseaseSemantic proximity Read

Computational design of new Peptide inhibitors for amyloid Beta (aβ) aggregation in Alzheimer's disease: application of a novel methodology.Semantic proximity Read

De novo designed protein inhibitors of amyloid aggregation and seedingSemantic proximity Read

Targeting GSK-beta with Peptide Inhibitors: A Rational Computational Strategy for Alzheimer's Disease InterventionSemantic proximity Read

APOE Genotype Difference in the Biphasic Modulation of Amyloid-β Aggregation by Direct Binding and Lowering the Nucleation Barrier.Semantic proximity Read