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Integrative bioinformatics analysis of APOE variants in Alzheimer's disease and clinical therapeutics.

Journal of biomolecular structure & dynamics - 1 Jun 2026

Srivastava Kshitij, Srivastava Ruby

Abstract excerpt

In this study, a comprehensive bioinformatics workflow is employed to investigate the impact of APOE gene variants on Alzheimer's disease (AD) and to explore their relevance for improving therapeutic strategies. Multiple databases were screened to identify key non-synonymous single nucleotide polymorphisms (nsSNPs) in APOE. Six variants: rs769452 (L46P), rs429358 (C130R), rs267606664 (G145D), rs121918393 (R154S),...

Topics

Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Apolipoproteins E

Polymorphism, Single Nucleotide

Molecular Docking Simulation

Computational Biology

Donepezil

Protein Binding

Mutation

Molecular Dynamics Simulation

Ligands

Piperidines

Models, Molecular

Protein Conformation

Source

Identifiers

PMID: 41355503
DOI: 10.1080/07391102.2025.2597291

Genes

APOE

Variants

rs769452
rs769452
rs769452
rs769452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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