Article

Single molecule fingerprinting reveals different growth mechanisms in seed amplification assays for different polymorphs of αSynuclein fibrils

2024-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-synuclein (αSyn) aggregates, detected in the biofluids of patients with Parkinson’s disease, have the ability to catalyze their own aggregation, leading to an increase in the number and size of aggregates. This self-templated amplification is used by newly developed assays to diagnose Parkinson’s disease and turned the presence of αSyn aggregates into a biomarker of the disease. It has bec...

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Literature Corpus work: 1dff3030-a22b-5042-a4ff-b77c90cbc690
DOI: 10.1101/2024.03.05.583619

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