Article

RNA interactions drive structural and functional diversification of α-Synuclein fibrils

2026-04-27

Abstract excerpt

<title>Abstract</title> <p>RNA has emerged as a modulator of protein aggregation, yet its structural and functional impact on amyloid assemblies remains unclear. Here we show that RNA acts as a cofactor that reshapes the assembly, structure and activity of α-synuclein (aS) fibrils, a central pathological hallmark of Parkinson’s disease. Although monomeric aS displays minimal RNA-binding propensity, aggregation co...

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Identifiers and source

Literature Corpus work: 3df2ba0f-5698-5974-9821-859a2003d528
DOI: 10.21203/rs.3.rs-9032720/v1

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