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Inducible T-Cell Co-Stimulator Emerges During Chronic Liver Disease Progression and Defines a T-Cell–Inflamed Immune State in Hepatocellular Carcinoma

2026-03-24

Abstract excerpt

<title>Abstract</title> <p>Background Hepatocellular carcinoma (HCC) arises within chronic liver disease and is molded by complex immune remodeling. Inducible T-cell costimulator (ICOS) is an immune checkpoint associated with T-cell activation, but its timing and role across disease progression remain unclear. This study aimed to clarify the stage-specific regulation of ICOS and determine its role in molding imm...

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Literature Corpus work
1dfbad89-051f-5c6f-8dd8-a19cfee02984
DOI
10.21203/rs.3.rs-9060848/v1
Open publication

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Inducible T-Cell Co-Stimulator Emerges During Chronic Liver Disease Progression and Defines a T-Cell–Inflamed Immune State in Hepatocellular CarcinomaDOI 10.21203/rs.3.rs-9060848/v1
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