Article

CR1(+) Tumor-Associated Macrophages Orchestrate an Immunosuppressive Niche in Hepatocellular Carcinoma: A Genetic and Multi-omics Dissection

2026-03-03

Abstract excerpt

<title>Abstract</title> <p> Background Hepatocellular carcinoma (HCC) is characterized by a profoundly immunosuppressive tumor microenvironment (TME), which severely limits therapeutic efficacy. By integrating a multi-omics strategy, we identified complement receptor 1 (CR1) as a central regulator of this immunosuppressive milieu. Methods We performed Mendelian randomization (MR) analyses to infer the causal r...

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Literature Corpus work: f0a188f0-296e-50ba-87bc-96a888e14a14
DOI: 10.21203/rs.3.rs-8712240/v1

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