Article
Single-cell profiling of human CD127+ innate lymphoid cells reveals diverse immune phenotypes in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) - 1 Oct 2022
He Yuanlin, Luo Jiajing, Zhang Guannan, Jin Yu, Wang Nanxi, Lu Jinying, Li Changxian, Guo Xiaohuan, Qin Na, Dai Juncheng, Chen Yun
Abstract excerpt
BACKGROUND AND AIMS: Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that play critical roles in cytokine-mediated regulation of homeostasis and inflammation. However, relationships between their immune phenotypic characteristics and HCC remain largely unexplored. APPROACH AND RESULTS: We performed single-cell RNA sequencing analysis on sorted hepatic ILC cells from human patients with HCC and...
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