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Article

Stage-dependent transcriptional regulation of ICOS across metabolic liver disease progression and hepatocellular carcinoma

2026-02-11

Abstract excerpt

<title>Abstract</title> <p>Background and Aim Metabolic dysfunction–associated steatotic liver disease (MASLD) can progress to metabolic dysfunction–associated steatohepatitis (MASH), cirrhosis, and eventually hepatocellular carcinoma (HCC). About 30% of HCC patients die within five years, highlighting an urgent need for early intervention and understanding of disease mechanisms. Immune dysregulation is a key fa...

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Literature Corpus work
e1b49c4e-51c5-5ae3-880e-544c2c478ed5
DOI
10.21203/rs.3.rs-8834306/v1
Open publication

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