Article

Evaluation of Estrogen Responsiveness and Sensitivity to Endocrine Therapy in ER-Positive Breast Cancer Organoids Using an Optimized Culture Medium

2026-08-31

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Approximately 20–30% of estrogen receptor (ER)-positive breast cancers exhibit early resistance to endocrine therapy. Conventional patient-derived organoid (PDO) culture media utilize high concentrations of growth factors that mask estrogen-dependent signals, thereby hindering functional sensitivity assays. This study aimed to develop an optimized culture medi...

Identifiers and source

Literature Corpus work: 1df5f3ef-418c-5cfe-9c03-9955d6edf353
DOI: 10.21203/rs.3.rs-10683624/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Evaluation of Estrogen Responsiveness and Sensitivity to Endocrine Therapy in ER-Positive Breast Cancer Organoids Using an Optimized Culture MediumDOI 10.21203/rs.3.rs-10683624/v1Read

Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancerSemantic proximity Read

Identifying the effectiveness of 3D culture systems to recapitulate breast tumor tissue in situ.Semantic proximity Read

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristicsSemantic proximity Read

Breast Cancer Organoids Model Patient-Specific Response to Drug TreatmentSemantic proximity Read

EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancerSemantic proximity Read

Tamoxifen Response at Single Cell Resolution in Estrogen Receptor-Positive Primary Human Breast TumorsSemantic proximity Read

Comparative characterization of OncoPro™ and Wnt-Based media reveals distinct phenotypic and pharmacologic states in patient-derived tumor organoidsSemantic proximity Read

In vitro drug testing using patient-derived ovarian cancer organoidsSemantic proximity Read

Breast Cancer MCF-7 Cell Spheroid Culture for Drug Discovery and DevelopmentSemantic proximity Read

Patient-derived response estimates from zero-passage organoids of luminal breast cancerSemantic proximity Read