Article

Ermin deficiency as an inside-out model of inflammatory dysmyelination

2020-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Ermin is an actin-binding protein found almost exclusively in the central nervous system (CNS) as a component of myelin sheaths. Although Ermin has been predicted to play a role in the formation and stability of myelin sheaths, this has not been directly examined in vivo . Here we show that Ermin is essential for myelin sheath integrity and normal saltatory conduction. Loss of Ermin in mice cau...

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Literature Corpus work: 1ddab0c5-923b-56b7-847b-7f0dfe07f846
DOI: 10.1101/2020.06.16.154781

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