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Article

Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Çolakoğlu Gülsen, Bergstrom-Tyrberg Ulrika, Berglund Erik O, Ranscht Barbara

Abstract excerpt

Myelin, a multilayered membrane sheath formed by oligodendrocytes around axons in the CNS, enables rapid nerve impulse conduction and sustains neuronal health. The signals exchanged between axons and oligodendrocytes in myelin remain to be fully elucidated. Here we provide genetic evidence for multiple and critical functions of Contactin-1 in central myelin. We document dynamic Contactin-1 expression on...

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Identifiers

PMID: 24385581
DOI: 10.1073/pnas.1313769110
PMCID: PMC3903244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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