Article
Ulk4 deficiency leads to hypomyelination in mice.
Glia - 1 Jan 2018
Liu Min, Xu Ping, Guan Zhenlong, Qian Xiaohong, Dockery Peter, Fitzgerald Una, O'Brien Timothy, Shen Sanbing
Abstract excerpt
Brain nerve fibers are insulated by myelin which is produced by oligodendrocytes. Defects in myelination are increasingly recognized as a common pathology underlying neuropsychiatric and neurodevelopmental disorders, which are associated with deletions of the Unc-51-like kinase 4 (ULK4) gene. Key transcription factors have been identified for oligodendrogenesis, but little is known about their associated...
Topics
- Animals
- Animals, Newborn
- Astrocytes
- Calcium-Binding Proteins
- Cerebral Cortex
- Demyelinating Diseases
- Disease Models, Animal
- Gene Expression Regulation, Developmental
- Glial Fibrillary Acidic Protein
- HMGB Proteins
- Homeobox Protein Nkx-2.2