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The X-Linked Intellectual Disability gene, <i>ZDHHC9</i> , is important for oligodendrocyte subtype determination and myelination

2023-08-08

Abstract excerpt

Two percent of patients with X-linked intellectual disability (XLID) exhibit loss-of-function mutations in the enzyme, ZDHHC9 . One of the main anatomical deficits observed in these patients is a decrease in corpus callosum volume and a concurrent disruption in white matter integrity. In this study, we demonstrate that deletion of Zdhhc9 in mice disrupts the balance of mature oligodendrocyte subtypes within the...

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Identifiers and source

Literature Corpus work
824ec589-7955-5d8f-8e1a-57d9cb287835
DOI
10.1101/2023.08.08.552342
Open publication

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The X-Linked Intellectual Disability gene, <i>ZDHHC9</i> , is important for oligodendrocyte subtype determination and myelinationDOI 10.1101/2023.08.08.552342
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