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Article

Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype.

Glia - 1 Dec 2022

Schacke Stephan, Kirkpatrick Joanna, Stocksdale Amy, Bauer Reinhard, Hagel Christian, Riecken Lars Björn, Morrison Helen

Abstract excerpt

Astrocytes are increasingly being recognized as contributors to physiological brain function and behavior. Astrocytes engage in glia-synaptic interactions through peripheral astrocyte processes, thus modulating synaptic signaling, for example, by handling glutamate removal from the synaptic cleft and (re)provision to axonal terminals. Peripheral astrocyte processes are ultrafine membrane protrusions rich in the...

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PMID: 35929192
DOI: 10.1002/glia.24253

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