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Catalytic activity of the prepilin peptidase PilD is required for full <i>P. aeruginosa</i> virulence in a nematode infection model

2025-07-10

Abstract excerpt

Pseudomonas aeruginosa is an ESKAPE pathogen of concern because of its antibiotic resistance and ability to colonize and infect humans in myriad diverse clinical settings, from the lungs of cystic fibrosis patients to burn wounds. Antivirulence strategies have emerged as an alternative to antibiotics for treating P. aeruginosa and other pathogens. One proposed antivirulence target is the prepilin peptidase PilD b...

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Identifiers and source

Literature Corpus work
1dca80f1-fb9a-5c0d-b18d-751b5dad0666
DOI
10.1101/2025.07.10.664072
Open publication

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Catalytic activity of the prepilin peptidase PilD is required for full <i>P. aeruginosa</i> virulence in a nematode infection modelDOI 10.1101/2025.07.10.664072
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