Article
Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa.
Science (New York, N.Y.) - 19 Feb 2010
Srinivas Nityakalyani, Jetter Peter, Ueberbacher Bernhard J, Werneburg Martina, Zerbe Katja, Steinmann Jessica, Van der Meijden Benjamin, Bernardini Francesca, Lederer Alexander, Dias Ricardo L A, Misson Pauline E, Henze Heiko, Zumbrunn Jürg, Gombert Frank O, Obrecht Daniel, Hunziker Peter, Schauer Stefan, Ziegler Urs, Käch Andres, Eberl Leo, Riedel Kathrin, DeMarco Steven J, Robinson John A
Abstract excerpt
Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a lead compound that was active in the nanomolar range against Gram-negative Pseudomonas spp., but was largely inactive against...
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