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Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death.

Cell host & microbe - 17 Apr 2013

Kirienko Natalia V, Kirienko Daniel R, Larkins-Ford Jonah, Wählby Carolina, Ruvkun Gary, Ausubel Frederick M

Abstract excerpt

The opportunistic pathogen Pseudomonas aeruginosa causes serious human infections, but effective treatments and the mechanisms mediating pathogenesis remain elusive. Caenorhabditis elegans shares innate immune pathways with humans, making it invaluable to investigate infection. To determine how P. aeruginosa disrupts host biology, we studied how P. aeruginosa kills C. elegans in a liquid-based pathogenesis model....

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Homeostasis
Hypoxia
Iron
Mutation
Pseudomonas aeruginosa
Transcription Factors
Virulence
Virulence Factors

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Identifiers

PMID: 23601103
DOI: 10.1016/j.chom.2013.03.003
PMCID: PMC3641844

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