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Article

Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression.

Scientific reports - 6 Apr 2017

Zeraati Mahdi, Moye Aaron L, Wong Jason W H, Perera Dilmi, Cowley Mark J, Christ Daniel U, Bryan Tracy M, Dinger Marcel E

Abstract excerpt

Cancer is a multifactorial disease driven by a combination of genetic and environmental factors. Many cancer driver mutations have been characterised in protein-coding regions of the genome. However, mutations in noncoding regions associated with cancer have been less investigated. G-quadruplex (G4) nucleic acids are four-stranded secondary structures formed in guanine-rich sequences and prevalent in the...

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Identifiers

PMID: 28386116
DOI: 10.1038/s41598-017-00739-y
PMCID: PMC5429658

Genes

BCL2
CXCL14
TAOK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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