Article

A VLP-based immunogen that elicits selective anti-Myostatin antibodies, enhances muscle mass and strength, and reduces adiposity

2026-04-08

Abstract excerpt

Myostatin (MSTN) is a TGFβ family ligand that restricts muscle growth. Genetic loss-of-function in MSTN increases muscle mass, reduces fat accumulation, and improves metabolic health in mice and humans, with no known adverse phenotypes. Thus, depleting MSTN has therapeutic potential for obesity, sarcopenia, and other muscle wasting conditions. Recently developed monoclonal antibodies (mAbs) targeting MSTN or its r...

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Literature Corpus work: 1d8c19d5-3661-5666-a72c-e62da1fe2847
DOI: 10.64898/2026.04.06.716693

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