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Article

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

12 Jun 2017

Abstract excerpt

The transforming growth factor-β (TGF-β) network of ligands and intracellular signaling proteins is a subject of intense interest within the field of skeletal muscle biology. To define the relative contribution of endogenous TGF-β proteins to the negative regulation of muscle mass via their activation of the Smad2/3 signaling axis, we used local injection of adeno-associated viral vectors (AAVs) encoding...

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PMID: 28607086
DOI: 10.1073/pnas.1620013114

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