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Article

GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2020

Parenté Alexis, Boukredine Axel, Baraige Fabienne, Duprat Nathalie, Gondran-Tellier Victor, Magnol Laetitia, Blanquet Véronique

Abstract excerpt

Muscle atrophy is associated with many diseases including genetic disorders, sarcopenia, or cachexia syndromes. Myostatin (Mstn), a transforming growth factor-beta (TGF-β) member, plays a key role in skeletal muscle homeostasis as a powerful negative regulator. Over the last decade, about 15 clinical trials aimed at inhibiting the Mstn pathway, failed to produce conclusive results. In this context, we...

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Identifiers

PMID: 31960486
DOI: 10.1096/fj.201901220R

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