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Article

Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice.

PloS one - 11 Feb 2010

Morine Kevin J, Bish Lawrence T, Pendrak Klara, Sleeper Meg M, Barton Elisabeth R, Sweeney H Lee

Abstract excerpt

BACKGROUND: Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia. Previously described approaches to blocking myostatin signaling include injection delivery of inhibitory propeptide domain or neutralizing antibodies. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe a unique method of myostatin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred mdx

Share to Muscular Dystrophy, Animal

Share to Muscular Dystrophy, Duchenne

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Source

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Identifiers

PMID: 20161803
DOI: 10.1371/journal.pone.0009176
PMCID: PMC2820101

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