Article

A <i>TP53</i> Intron-Derived Non-Canonical Protein Promotes Tumor Survival

2025-09-09

Abstract excerpt

<h4>SUMMARY</h4> During transcription, alternative cleavage and polyadenylation (APA) of transcripts produces mRNAs that differ in their 3’ ends. We previously found that leukemia cells cleave and polyadenylate transcripts within introns (intronic A PA , IPA) to generate truncated RNA isoforms, which perturb the expression and function of corresponding genes. In addition to protein-coding RNA, we found that leuk...

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Literature Corpus work: 1d89e259-5245-55b3-ad55-96b87b459c88
DOI: 10.1101/2025.09.04.674312

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