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Alternative polyadenylation dysregulation contributes to the differentiation block of acute myeloid leukemia

6 Sept 2021

Abstract excerpt

Posttranscriptional regulation has emerged as a driver for leukemia development and an avenue for therapeutic targeting. Among posttranscriptional processes, alternative polyadenylation (APA) is globally dysregulated across cancer types. However, limited studies have focused on the prevalence and role of APA in myeloid leukemia. Furthermore, it is poorly understood how altered poly(A) site usage of individual...

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PMID: 34482400
DOI: 10.1182/blood.2020005693

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