Article

Resmetirom Attenuates Atherosclerosis in ApoE ⁻/⁻ Mice by Suppressing the NF- κB/ROS–NLRP3 Inflammasome Axis

2026-02-24

Abstract excerpt

<title>Abstract</title> <p> Atherosclerosis is a chronic inflammatory vascular disease in which the NLRP3 inflammasome and NF-κB signaling play central pathogenic roles. Resmetirom, a liver-selective thyroid hormone receptor β (THR-β) agonist approved for metabolic dysfunction-associated steatohepatitis (MASH), exhibits potent lipid-lowering effects, yet its anti-inflammatory actions in atherosclerosis remain un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bdb9d0b-5862-58a1-bf9b-70e18fd72a7b
DOI: 10.21203/rs.3.rs-8902352/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resmetirom Attenuates Atherosclerosis in ApoE ⁻/⁻ Mice by Suppressing the NF- κB/ROS–NLRP3 Inflammasome AxisDOI 10.21203/rs.3.rs-8902352/v1Read

Modulation of metabolic, inflammatory, fibrotic and cell death pathways by Resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): A transcriptomic profiling studySemantic proximity Read

Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and AtherosclerosisSemantic proximity Read

Gasdermin D mediates inflammation-induced defects in reverse cholesterol transport and promotes atherosclerosisSemantic proximity Read

Portrayal of NLRP3 Inflammasome in Atherosclerosis: Current Knowledge and Therapeutic TargetsSemantic proximity Read

Artesunate inhibits macrophage-like phenotype switching of vascular smooth muscle cells and attenuates vascular inflammatory injury in atherosclerosis via NLRP3.Semantic proximity Read

Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axisSemantic proximity Read

Innate Immune Pathways in Atherosclerosis – from Signaling to Long-Term Epigenetic ReprogrammingSemantic proximity Read

The Anti-Atherosclerotic Action of FFAR4 Agonist TUG-891 in ApoE-Knockout Mice Is Associated with Increased Macrophage Polarization towards M2 Phenotype.Semantic proximity Read

The anti-atherosclerosis effect of anakinra, a recombinant human interleukin-1 receptor antagonist, in apolipoprotein E knockout miceSemantic proximity Read

Beyond the Foam Cell: The Role of LXRs in Preventing AtherogenesisSemantic proximity Read

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver diseaseSemantic proximity Read

Nitazoxanide reduces atherosclerosis by decreasing polarization of macrophages to proinflammatory M1 phenotype via inhibition of NF-κB pathway.Semantic proximity Read