Article

Protein expression profiles in brain organoids are more similar to those in human brain parenchyma than in mouse brain parenchyma

2023-09-15

Abstract excerpt

<h4>Summary</h4> Human brain organoids are emerging as relevant models for the study of human brain health and disease. However, it has not been shown whether human brain organoids exhibit a proteoform profile similar to the human brain. Herein, we demonstrate that unguided brain organoids exhibit minimal batch-to-batch variability in cell composition and metabolism when generated from induced pluripotent stem ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d819a54-db04-5076-ba00-9735cb4bb0a6
DOI: 10.1101/2023.09.12.557448

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protein expression profiles in brain organoids are more similar to those in human brain parenchyma than in mouse brain parenchymaDOI 10.1101/2023.09.12.557448Read

Optimization and scaling of patient-derived brain organoids uncovers deep phenotypes of diseaseSemantic proximity Read

Brain Organoids: A Promising Living Biobank Resource for Neuroscience Research.Semantic proximity Read

Reconstitution of Human Brain Cell Diversity in Organoids via Four ProtocolsSemantic proximity Read

The RNA and protein landscapes of mouse brain organoidsSemantic proximity Read

Multi-omic analysis of guided and unguided forebrain organoids reveal differences in cellular composition and metabolic profilesSemantic proximity Read

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.Semantic proximity Read

Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architectureSemantic proximity Read

Temporal proteomic and PTMomic atlas of cerebral organoid developmentSemantic proximity Read

Optimizing PSC culture for generating neural organoidsSemantic proximity Read

Parsing the effect of co-culture with brain organoids on Diffuse Intrinsic Pontine Glioma (DIPG) using quantitative proteomicsSemantic proximity Read

Establishing Cerebral Organoids as Models of Human-Specific Brain EvolutionSemantic proximity Read

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion, and drug screeningSemantic proximity Read