Article

Design and synthesis of inhibitors for N-myristoyltransferase, a promising treatment for parasitic diseases

2011-01-01

Abstract excerpt

N-myristoyltransferase (NMT) is a monomeric enzyme, which is ubiquitous in eukaryotes, catalysing an irreversible co-translational transfer of myristate to a particular set of proteins containing an N-terminal glycine. The work presented in this thesis illustrates the use of synthesised small molecules as a probe to investigate the role of NMT in parasites. Chapter 1 looks at the two parasitic diseases that this p...

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Literature Corpus work: 4bb17507-fe67-5d92-a65b-ff7cc99c425e
DOI: 10.25560/10191

Open publication

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