Article

Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity

2020-10-29

Abstract excerpt

<h4>Background</h4> Monoamine neurotransmitter abundance affects motor control, emotion, and cognitive function and is regulated by monoamine oxidases. Amongst these, monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Loss-of-function mutations in the X-linked MAOA gene cause Brunner syndrome, which is characterized by various forms of...

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Literature Corpus work: 8567b6e5-c860-52d8-9b1f-7f2eff714e3e
DOI: 10.1101/2020.10.28.359224

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