Article
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.
Cell - 29 Oct 2020
Wells Daniel K, van Buuren Marit M, Dang Kristen K, Hubbard-Lucey Vanessa M, Sheehan Kathleen C F, Campbell Katie M, Lamb Andrew, Ward Jeffrey P, Sidney John, Blazquez Ana B, Rech Andrew J, Zaretsky Jesse M, Comin-Anduix Begonya, Ng Alphonsus H C, Chour William, Yu Thomas V, Rizvi Hira, Chen Jia M, Manning Patrice, Steiner Gabriela M, Doan Xengie C, Merghoub Taha, Guinney Justin, Kolom Adam, Selinsky Cheryl, Ribas Antoni, Hellmann Matthew D, Hacohen Nir, Sette Alessandro, Heath James R, Bhardwaj Nina, Ramsdell Fred, Schreiber Robert D, Schumacher Ton N, Kvistborg Pia, Defranoux Nadine A
Abstract excerpt
Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, there are no reference data to compare these approaches, and the parameters governing tumor epitope immunogenicity remain unclear. Here, we assembled a global consortium wherein each participant predicted immunogenic epitopes from...
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