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Colistin resistance mutations in <i>phoQ</i> sensitize <i>Klebsiella pneumoniae</i> to IgM-mediated complement killing

2022-09-15

Abstract excerpt

The Gram-negative bacterium Klebsiella pneumoniae is notorious for a strong increase of infections with antibiotic resistant strains. To treat infections with antibiotic resistant K. pneumoniae, clinicians increasingly need to use the last resort antibiotic colistin. K. pneumoniae can develop colistin resistance by modifying its membranes. During infection the membranes of Gram-negative bacteria are also target...

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Literature Corpus work
1d5a9fff-2a18-5c06-bb57-cfce662a0008
DOI
10.1101/2022.09.15.508115
Open publication

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Colistin resistance mutations in <i>phoQ</i> sensitize <i>Klebsiella pneumoniae</i> to IgM-mediated complement killingDOI 10.1101/2022.09.15.508115
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