Article

Terminal complement complexes with or without C9 potentiate antimicrobial activity against <i>Neisseria gonorrhoeae</i>

2025-01-16

Abstract excerpt

The complement cascade is a front-line defense against pathogens. Complement activation generates the membrane attack complex (MAC), a 10-11 nm diameter pore formed by complement proteins C5b through C8 and polymerized C9. The MAC embeds within the outer membrane of Gram-negative bacteria and displays bactericidal activity. In the absence of C9, C5b-C8 complexes can form 2-4 nm pores on membranes, but their releva...

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Literature Corpus work: f7a6cd71-a26b-5b20-ba98-3ce2870b2186
DOI: 10.1101/2025.01.16.633325

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