Article

Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of <i>Klebsiella pneumoniae</i>

2025-12-18

Abstract excerpt

Membrane Attack Complex (MAC) pores are important in the human innate immune response to directly kill pathogenic Gram-negative bacteria. MAC pores assemble when complement proteins in serum are activated on bacteria and convert complement protein C5 into C5b, which together with C6, C7, C8, and multiple copies of C9 form a pore that damages the bacterial envelope. Due to rising multidrug-resistant infections with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fcdcc293-931e-5b0e-9687-012a1e24584d
DOI: 10.64898/2025.12.16.694563

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of <i>Klebsiella pneumoniae</i>DOI 10.64898/2025.12.16.694563Read

Complement resistance mechanisms of Klebsiella pneumoniaeSemantic proximity Read

Colistin resistance mutations in <i>phoQ</i> sensitize <i>Klebsiella pneumoniae</i> to IgM-mediated complement killingSemantic proximity Read

Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5Semantic proximity Read

Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing.Semantic proximity Read

Terminal complement complexes with or without C9 potentiate antimicrobial activity against <i>Neisseria gonorrhoeae</i>Semantic proximity Read

The capsule of hypervirulent <i>Klebsiella pneumoniae</i> maintains neutrophils in neutral activation stateSemantic proximity Read

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infectionSemantic proximity Read

Catch Me if You Can: Streptococcus pyogenes Complement Evasion StrategiesSemantic proximity Read

Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against <i>Streptococcus pneumoniae</i>Semantic proximity Read

Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum.Semantic proximity Read

Interactions between Neisseria meningitidis and the complement system.Semantic proximity Read

The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel TherapeuticsSemantic proximity Read