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Unrecognized Potent Activities of Colistin Against Clinically Important <i>mcr</i> + Enterobacteriaceae Revealed in Synergy with Host Immunity

2023-03-21

Abstract excerpt

<h4>ABSTRACT</h4> Colistin (COL) is a cationic cyclic peptide that disrupts negatively-charged bacterial cell membranes and frequently serves as an antibiotic of last resort to combat multidrug-resistant Gram-negative bacterial infections. Emergence of the horizontally transferable plasmid-borne mobilized colistin resistance ( mcr ) determinant and its spread to Gram-negative strains harboring extended-spectrum...

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Literature Corpus work
c24d1aec-b5c7-59fe-b480-308a666fdf80
DOI
10.1101/2023.03.21.533661
Open publication

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Unrecognized Potent Activities of Colistin Against Clinically Important <i>mcr</i> + Enterobacteriaceae Revealed in Synergy with Host ImmunityDOI 10.1101/2023.03.21.533661
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