Article

The capsule of hypervirulent <i>Klebsiella pneumoniae</i> maintains neutrophils in neutral activation state

2026-02-25

Abstract excerpt

Hypervirulent Klebsiella pneumoniae (hvKp) cause invasive infections despite robust neutrophil recruitment, yet the mechanisms enabling persistence in neutrophil-rich environments remain poorly defined. Here, we show that hvKp do not simply resist neutrophil antimicrobial mechanisms but instead constrain neutrophils into a neutral functional state characterised by limited bactericidal activity. Using genetic diss...

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Literature Corpus work: c1a5607b-bbd0-57a1-b1b1-e9f4063f8b79
DOI: 10.64898/2026.02.24.707717

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