Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing.

Scientific reports - 3 Aug 2023

van der Lans Sjors P A, Janet-Maitre Manon, Masson Frerich M, Walker Kimberly A, Doorduijn Dennis J, Janssen Axel B, van Schaik Willem, Attrée Ina, Rooijakkers Suzan H M, Bardoel Bart W

Abstract excerpt

Due to multi-drug resistance, physicians increasingly use the last-resort antibiotic colistin to treat infections with the Gram-negative bacterium Klebsiella pneumoniae. Unfortunately, K. pneumoniae can also develop colistin resistance. Interestingly, colistin resistance has dual effects on bacterial clearance by the immune system. While it increases resistance to antimicrobial peptides, colistin resistance has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colistin

Share to Drug Resistance, Bacterial

Share to Immunoglobulin M

Share to Klebsiella Infections

Share to Klebsiella pneumoniae

Share to Microbial Sensitivity Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 37537263
DOI: 10.1038/s41598-023-39613-5
PMCID: PMC10400624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing.PMID 37537263Read ↗

Colistin resistance mutations in <i>phoQ</i> sensitize <i>Klebsiella pneumoniae</i> to IgM-mediated complement killingSemantic proximity Read ↗

Complement resistance mechanisms of Klebsiella pneumoniaeSemantic proximity Read ↗

The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel TherapeuticsSemantic proximity Read ↗

Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of <i>Klebsiella pneumoniae</i>Semantic proximity Read ↗

Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical originSemantic proximity Read ↗

Understanding Recent Developments in Colistin Resistance: Mechanisms, Clinical Implications, and Future PerspectivesSemantic proximity Read ↗

Interactions and Implications of Klebsiella pneumoniae with Human Immune Responses and Metabolic Pathways: A Comprehensive ReviewSemantic proximity Read ↗

Colistin Resistance Mechanisms in Human and Veterinary Klebsiella pneumoniae IsolatesSemantic proximity Read ↗

Assessing the efficacy of therapeutically promising combination of polymyxin B and triclosan against colistin-resistant <i>Klebsiella pneumoniae</i>Semantic proximity Read ↗

Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.Semantic proximity Read ↗

Unrecognized Potent Activities of Colistin Against Clinically Important <i>mcr</i> + Enterobacteriaceae Revealed in Synergy with Host ImmunitySemantic proximity Read ↗

Proteomic Changes of Klebsiella pneumoniae in Response to Colistin Treatment and crrB Mutation-Mediated Colistin Resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.