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Article

POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition.

Cell cycle (Georgetown, Tex.) - 1 Jun 2022

Chen Anbin, Kristiansen Cecilie Katrin, Høyland Lena Elise, Ziegler Mathias, Wang Jian, Sullivan Gareth John, Li Xingang, Bindoff Laurence A, Liang Kristina Xiao

Abstract excerpt

We showed previously that POLG mutations cause major changes in mitochondrial function, including loss of mitochondrial respiratory chain (MRC) complex I, mitochondrial DNA (mtDNA) depletion and an abnormal NAD+/NADH ratio in both neural stem cells (NSCs) and astrocytes differentiated from induced pluripotent stem cells (iPSCs). In the current study, we looked at mitochondrial remodeling as stem cells transit...

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AMP-Activated Protein Kinases
Astrocytes
DNA Polymerase gamma
Electron Transport Complex I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neural Stem Cells

Pluripotent Stem Cells

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PMID: 35298342
DOI: 10.1080/15384101.2022.2044136
PMCID: PMC9103491

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POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition.PMID 35298342Read ↗

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