Article
Deterministic evolution and stringent selection during pre-neoplasia
2022-04-10
Abstract excerpt
The earliest events during human tumor initiation, while poorly characterized, may hold clues to malignancy detection and prevention 1 . Here we model occult pre-neoplasia by bi-allelically inactivating TP53 , a common early event in gastric cancer, in human gastric organoids. Causal relationships between this initiating genetic lesion and resulting phenotypes were established using experimental evolution in mul...
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Identifiers and source
- Literature Corpus work
- fc44bd09-f75e-5ddb-9957-ae49e0c94b08
- DOI
- 10.1101/2022.04.09.487529