Article

Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

2021-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Targeting MAIT cells holds promise for the treatment of different diseases and infections. We previously showed that treatment of Mycobacterium tuberculosis infected mice with 5-OP-RU, a major antigen for MAIT cells, expands MAIT cells and enhances bacterial control. Here we treated M. tuberculosis infected rhesus macaques with 5-OP-RU intratracheally but found no clinical or microbiological b...

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Literature Corpus work: 69d36490-8bf8-576d-be4f-c1e2585220ea
DOI: 10.1101/2021.01.29.428844

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