Article
Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk.
Human molecular genetics - 15 Sept 2018
Xia Hanzhang, Jahr Fay M, Kim Nak-Kyeong, Xie Linying, Shabalin Andrey A, Bryois Julien, Sweet Douglas H, Kronfol Mohamad M, Palasuberniam Preetha, McRae MaryPeace, Riley Brien P, Sullivan Patrick F, van den Oord Edwin J, McClay Joseph L
Abstract excerpt
The transcription factor 4 (TCF4) locus is a robust association finding with schizophrenia (SCZ), but little is known about the genes regulated by the encoded transcription factor. Therefore, we conducted chromatin immunoprecipitation sequencing (ChIP-seq) of TCF4 in neural-derived (SH-SY5Y) cells to identify genome-wide TCF4 binding sites, followed by data integration with SCZ association findings. We identified...
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