Article

P2X7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study

2024-04-01

Abstract excerpt

<title>Abstract</title> <p>Background PET imaging of activated microglia has improved our understanding of the pathology behind disability progression in MS, and pro-inflammatory microglia at ‘smoldering’ lesion rims have been implicated as drivers of disability progression. The P2X<sub>7</sub>R is upregulated in the cellular membranes of activated microglia. A single-tissue dual-input model was applied to quant...

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Literature Corpus work: 1d024935-cff5-5a12-9236-a365cf913bc6
DOI: 10.21203/rs.3.rs-4121612/v1

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