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Phenotyping in vivo chronic inflammation in multiple sclerosis by combined 11C-PBR28 MR-PET and 7T susceptibility-weighted imaging.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2024

Treaba Constantina A, Herranz Elena, Barletta Valeria T, Mehndiratta Ambica, Sloane Jacob A, Granberg Tobias, Miscioscia Alessandro, Bomprezzi Roberto, Loggia Marco L, Mainero Caterina

Abstract excerpt

BACKGROUND: 11C-PBR28 positron emission tomography (PET), targeting the translocator protein, and paramagnetic rim lesions (PRL) have emerged as promising imaging markers of MS chronic inflammation. No consensus on which is the optimal marker exists. OBJECTIVES: To investigate the ability of 11C-PBR28 PET and PRL assessment to identify chronic inflammation in white matter (WM) MS lesions and their relation to...

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PMID: 39436837
DOI: 10.1177/13524585241284157

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