Article

Attenuated Acute Microglial Responsiveness in Participants with Alzheimer's Disease: An In Vivo LPS Challenge [11C]PBR28 TSPO-PET Pilot Study

2026-03-04

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Elevated TSPO-PET binding in Alzheimer's disease (AD) is widely interpreted as increased microglial activity, yet whether these cells retain functional capacity for responses protective against amyloid and other pathologies remains unknown. We conducted a proof-of-concept study using in vivo lipopolysaccharide (LPS) challenge to assess dynamic microglial resp...

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Literature Corpus work: fef0fcf1-c23f-5438-a0f1-2b1e2e56c6bd
DOI: 10.21203/rs.3.rs-9012605/v1

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