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The DNA damage response is required for oocyte cyst breakdown and follicle formation in mice

18 Nov 2020

Abstract excerpt

Mammalian oogonia proliferate without completing cytokinesis, forming cysts. Within these, oocytes differentiate and initiate meiosis, promoting double-strand break (DSBs) formation, which are repaired by homologous recombination (HR) causing the pairing and synapsis of the homologs. Errors in these processes activate checkpoint mechanisms, leading to apoptosis. At the end of prophase I, in contrast with what is...

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PMID: 33206637
DOI: 10.1371/journal.pgen.1009067

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