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Article

FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition

22 Oct 2020

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) associated with high-risk human papilloma virus (HPV) infection is a growing clinical problem. The WEE1 kinase inhibitor AZD1775 (WEE1i) overrides cell cycle checkpoints and is being studied in HNSCC regimens. We show that the HPV16 E6/E7 oncoproteins sensitize HNSCC cells to single-agent WEE1i treatment through activation of a FOXM1-CDK1 circuit that drives mitotic...

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PMID: 33093209
DOI: 10.1073/pnas.2013921117

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