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Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastoma

2025-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Effective therapies for high-risk medulloblastoma (MB), particularly MYC-driven Group 3 (G3) MB, remain elusive due to limited druggable mutations, poor blood–brain barrier (BBB) penetration, and rapid resistance. We developed SINBA ( Synergy Inference by Data-driven Network-Based Bayesian Analysis ), a systems biology framework that computationally prioritizes synergistic, BBB-permeable drug...

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Literature Corpus work
150b8621-a129-5e9a-a600-5d206d35f309
DOI
10.1101/2025.11.20.689490
Open publication

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Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastomaDOI 10.1101/2025.11.20.689490
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