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Systematic elucidation and pharmacologic targeting of non-oncogene dependencies in imatinib-resistant gastrointestinal stromal tumor

2025-10-14

Abstract excerpt

Treatment of gastrointestinal stromal tumor (GIST) with imatinib and other KIT-targeting drugs has improved outcomes significantly. However, most patients with advanced GIST eventually develop imatinib resistance and succumb to disease. We have developed mutation-agnostic, network-based methodologies to systematically elucidate and pharmacologically target Master Regulator (MR) proteins—critical non-oncogene depen...

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Literature Corpus work
c05e9bb1-d40d-549c-9cf3-c5a07f2f6998
DOI
10.1101/2025.10.12.681609
Open publication

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Systematic elucidation and pharmacologic targeting of non-oncogene dependencies in imatinib-resistant gastrointestinal stromal tumorDOI 10.1101/2025.10.12.681609
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