Article

Jatrorrhizine suppresses high-fat diet-associated colorectal cancer by modulating the ATX-LPA-LPAR- MAPK axis to regulate glycerophospholipid metabolism

2026-05-22

Abstract excerpt

<title>Abstract</title> <p>High-fat diet (HFD) intake is positively correlated with the incidence of colorectal cancer (CRC). It drives CRC through complex mechanisms, yet clinical treatments remain limited, necessitating new strategies. Modern pharmacological studies show that jatrorrhizine (JAT) possesses various biological activities, including antibacterial, antiinflammatory, antiobesity, lipid-lowering, and...

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Literature Corpus work: 1cba4f9e-c6bf-53ae-9a4d-c6c089dc0f99
DOI: 10.21203/rs.3.rs-9543581/v1

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